P036: Digoxin immune fab treatment for digoxin and non-digoxin cardioactive steroid toxicity: a scoping review
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چکیده
منابع مشابه
Digoxin Immune Fab (Ovine)
Digibind, digoxin immune Fab (ovine), is a sterile lyophilized powder of antigen binding fragments (Fab) derived from specific antidigoxin antibodies raised in sheep. Production of antibodies specific for digoxin involves conjugation of digoxin as a hapten to human albumin. Sheep are immunized with this material to produce antibodies specific for the antigenic determinants of the digoxin molecu...
متن کاملDigoxin Toxicity and Use of Digoxin Immune Fab: Insights From a National Hospital Database.
OBJECTIVES This study was developed to determine contemporary management of digoxin toxicity and clinical outcomes. BACKGROUND Although the use of digoxin in heart failure management has declined, toxicity remains a prevalent complication. METHODS The Premier Perspective Comparative Hospital Database (Premier Inc., Charlotte, North Carolina) was used to retrospectively identify patients dia...
متن کاملAnalysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity.
BACKGROUND Studies indicate that digoxin toxicity often results in lengthy hospitalizations and considerable costs, both of which may be decreased through the routine use of digoxin immune Fab (FAB). METHODS A computer-based decision analysis model was developed to compare the treatment of non-life-threatening digoxin toxicity with either FAB or standard therapy from the hospital perspective....
متن کاملContrasting rates of reversal of digoxin toxicity by digoxin-specific IgG and Fab fragments.
Both heterologous IgG and Fab fragments of appropriate affinity and specificity have been shown capable of reversing advanced cardiac glycoside toxicity. Fab fragments are more rapidly excreted and theoretically have a smaller risk of unwanted immunologic effects, but relative rates of toxicity reversal have not been established. Rates of reversal of advanced digoxin toxicity by digoxin-specifi...
متن کاملClarithromycin induced digoxin toxicity.
A case of digoxin poisoning following the co-administration of digoxin and clarithromycin in a 28 year old male is described. Since the aetiology of chronic digoxin poisoning is often unclear, clinicians should be aware of the potential drug-drug interaction between digoxin and clarithromycin.
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ژورنال
عنوان ژورنال: CJEM
سال: 2019
ISSN: 1481-8035,1481-8043
DOI: 10.1017/cem.2019.227